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KMID : 0043320050280121324
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Archives of Pharmacal Research
2005 Volume.28 No. 12 p.1324 ~ p.1327
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Monoamine Oxidase Inhibitory Constituents from the Fruits of Cudrania tricuspidata
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Han Xiang Hua
Hong Seong-Soo
Hwang Ji-Sang
Jung Sun-Hwa
Hwang Ji-Hye
Lee Min-Hee
Lee Myung-Koo
Lee Dong-Ho
Ro Jai-Seup
Hwang Bang-Yeon
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Abstract
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A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4’-O-methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with values of 19.4, 23.9, and 25.8 M, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B ( 0.8 M) than MAO-A ( >800 M). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.
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KEYWORD
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Cudrania tricuspidata, Moraceae, Prenylated isoflavone, Gancaonin A, Monoamine oxidase inhibitor
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